NOTICE
In light of the growing concerns around COVID-19, and recent decisions passed down within Allegheny County/City of Pittsburgh, our Seminars’ Schedule is being closely monitored and are continuously changing/being cancelled. We will work to keep this website as updated as possible, so please check back often. Thank you for your patience and understanding.
Pittsburgh Center for Evolutionary Biology and Medicine (CEBaM)
The mission of the Center is to advance the fields of evolutionary biology and medicine by catalyzing research at their interface. The Center serves to cultivate educational and scientific collaborations between evolutionary biologists and biomedical researchers.
News & Events
CEBaM Seminar: Erik Wright – September 21, 2021
2021-2022 CEBaM Seminar Series September 21, 202112:00 – 1:00 pm Hybrid EventRegister for an in-person…
Identification of antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results
Some antibiotic pairs display a property known as collateral
Viral parasites fuel evolution of drug-resistant ‘super bugs’
Tiny viruses that attack bacteria, known as phages, are responsible for the rapid evolution of bacterial defense systems and the emergence of so-called superbugs, according to a new study.
Recent Publications
Koenig KM, Gross JM. (2020) Evolution and development of complex eyes: a celebration of diversity. Development.
Chilambi GS, Nordstrom HR, Evans DR, Ferrolino JA, Hayden RT, Maron GM, Vo AN, Gilmore MS, Wolf J, Rosch JW, Van Tyne D. (2020) Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients. Proc Natl Acad Sci USA.
Evans DR, Griffith MP, Sundermann AJ, Shutt KA, Saul MI, Mustapha MM, Marsh JW, Cooper VS, Harrison LH, Van Tyne D. (2020) Systematic detection of horizontal gene transfer across genera among multidrug-resistant bacteria in a single hospital. eLife.
Vakirlis N, Carvunis AR, McLysaght A. (2020) Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes. Elife.
Vakirlis N, Acar O, Hsu B, Castiho Coelho N, Van Oss SB, Wacholder A, Medetgul-Ernar K, Bowman RW 2nd, Hines CP, Iannotta J, Parikh SB, McLysaght A, Camacho CJ, O’Donnell AF, Ideker T, Carvunis AR. (2020) De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences. Nat Commun.
Keeling DM, Garza P, Nartey CM, Carvunis AR. (2020) The Recalcitrance and Resilience of Scientific Function. Poroi.
Melody K, Roy CN, Kline C, Cottrell ML, Evans D, Shutt K, Pennings PS, Keele BF, Bility M, Kashuba ADM, Ambrose Z. (2020) Long-Acting Rilpivirine (RPV) Preexposure Prophylaxis Does Not Inhibit Vaginal Transmission of RPV-Resistant HIV-1 or Select for High-Frequency Drug Resistance in Humanized Mice. J Virol.
Smith SJ, Davidson LA, Rebeiz M. (2020) Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure. Elife.
Morgenthaler AB, Kinney WR, Ebmeier CC, Walsh CM, Snyder DJ, Cooper VS, Old WM, Copley SD. (2019) Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome. Elife.
Club EvMed is a web series launched in April 2020 to keep the evolutionary medicine community connected during a time of pandemic-related social distancing. These regularly-held virtual meetings are styled around the idea of a journal club, with a different topic and discussion leader each time.