Pittsburgh Center for Evolutionary Biology and Medicine (CEBaM)
The mission of the Center is to advance the fields of evolutionary biology and medicine by catalyzing research at their interface. The Center serves to cultivate educational and scientific collaborations between evolutionary biologists and biomedical researchers.
News & Events
Morgenthaler AB, Kinney WR, Ebmeier CC, Walsh CM, Snyder DJ, Cooper VS, Old WM, Copley SD. (2019) Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome. Elife.
Patel RK, Weir MC, Shen K, Snyder D, Cooper VS, Smithgall TE. (2019) Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. PLoS One.
Kim J, Flood JJ, Kristofich MR, Gidfar C, Morgenthaler AB, Fuhrer T, Sauer U, Snyder D, Cooper VS, Ebmeier CC, Old WM, Copley SD. (2019) Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB. Proc Natl Acad Sci USA.
Turner CB, Buskirk SW, Harris KB, Cooper VS. (2019) Negative frequency-dependent selection maintains coexisting genotypes during fluctuating selection. Mol Ecol.
Bias AS, Kostka D. (2019) scds: Computational Annotation of Doublets in Single-Cell RNA Sequencing Data. Bioinformatics.
Benton ML, Talipineni SC, Kostka D, Capra Ja. (2019) Genome-wide enhancer annotations differ significantly in genomic distribution, evolution, and function. BMC Genomics.
Santos-Lopez A, Marshall CW, Scribner MR, Snyder DJ, Cooper VS. (2019) Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle. Elife 13;8. doi: 10.7554/eLife.47612.
Hall AE, Karkare K, Cooper VS, Bank C, Cooper TF, Moore FB. (2019) Environment changes epistasis to alter trade-offs along alternative evolutionary paths. Evolution. doi: 10.1111/evo.13825.